A Karim Benzema hat-trick has given Chelsea a mountain to climb if they're to reach the Champions League semi-finals.
Real Madrid ran out 3-1 winners at Stamford Bridge last night thanks to the French striker.
Elsewhere, Villarreal were one-nil winners at home to Bayern Munich in the first leg of their quarter final.
Everton's relegation fears intensified last night, with a 3-2 defeat away to Burnley in the Premier League.
Republic of Ireland defender Nathan Collins opened the scoring for the hosts, with Maxwell Cornet (pr: Cor-nay) sweeping home the winner three minutes from time.
The win moves Burnley to within a point of fourth-from-bottom Everton.
West Ham play a European quarter-final for the first time since 1981 tonight.
They welcome Lyon to the London stadium in the first leg of their Europa League last-8 tie.
Elsewhere, Rangers are in Portugal to play Braga.
Tonight's other games see Barcelona away to Eintracht Frankfurt, and R-B Leipzig play Atalanta.
While in the Conference League quarter-finals, Leicester entertain PSV Eindhoven.
